HEPTRAL (Ademetionine, S-Adenosylmethionine, SAMe) Trablets or Injectable

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GEPTRAL (Ademetionine, S-Adenosylmethionine, SAMe) is used in the treatment of liver disease. It is used in liver condition associated with reduced bile formation (intrahepatic cholestasis). Ademetionine protects the liver cells from toxins and helps the liver to perform its normal functions. Is also used as a drug in Europe for the treatment of depression, liver disorders, fibromyalgia and osteoarthritis. It has also been introduced into the United States market as a dietary supplement for the support of bone and joint health, as well as mood and emotional well being.


  • Fatty degeneration of the liver.
  • Chronic hepatitis.
  • Toxic liver damage of various etiologies, including alcoholic, viral, medicinal (antibiotics; antineoplastic, anti-tuberculosis and antiviral drugs, tricyclic antidepressants, oral contraceptives).
  • Chronic acalculous cholecystitis.
  • Cholangitis.
  • Cirrhosis of the liver.
  • Encephalopathy, including associated with liver failure (alcohol, etc.).
  • Intrahepatic cholestasis in pregnant women.
  • Symptoms of depression.
  • Moderate arterial hypotension.

100% original from Italian AbbVie S.r.L. Expiry date up to 03.2026.

S-adenosylmethionine is an intermediate metabolite of methionine. Its involvement in methylation assists in cellular growth and repair, maintains the phospho-bilipid layer in cell membranes. It also helps in the maintenance of the action of several hormones and neurotransmitters that affect mood. Highest concentration are found in the brain and the liver.
S-Adenosylmethionine (SAMe) is a natural substance present in the cells of the body. It is a direct metabolite of the essential amino acid L-methionine. SAMe plays a crucial biochemical role in the body by donating a one-carbon methyl group in a process called transmethylation. SAMe, formed from the reaction of L-methionine and adenosine triphosphate catalyzed by the enzyme S-adenosylmethionine synthetase, is the methyl-group donor in the biosynthesis of both DNA and RNA nucleic acids, phospholipids, proteins, epinephrine, melatonin, creatine and other molecules.

The medication is taken orally. The tablets should be taken whole, without chewing, preferably in the morning, between meals.
Active ingredient: Ademetionine - 500 mg.
Excipients: colloidal silicon dioxide - 5.50 mg, microcrystalline cellulose - 118.00 mg, sodium carboxymethyl starch (type A) - 22.00 mg, magnesium stearate - 5.50 mg; tablet shell: methacrylic acid and ethyl acrylate copolymer (1: 1) - 32.63 mg, macrogol-6000 - 9.56 mg, polysorbate-80 - 0.52 mg, simethicone emulsion (30%) - 0.40 mg, sodium hydroxide - 0.44 mg, talc - 21.77 mg.

Initial therapy: The recommended dose is 10-25 mg per 1 kg of body weight per day.
Intrahepatic cholestasis, fatigue in chronic liver disease: 800 to 1600 mg per day.
Depression: 800 to 1600 mg per day. The duration of therapy is determined by the doctor.

It is recommended to store the medicine in a dark place at a temperature not exceeding 25°C.

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