NEBIVOLOL is used in the management and treatment of hypertension. It is in the beta-blocker class of drugs. This activity describes the indications, action, and contraindications for this medication as a valuable agent in managing hypertension and patients with vascular disease. Beta-blockers fall into two categories based on whether they block beta-1 receptors in cardiac muscles, beta-2 receptors in the lungs and smooth muscles, or both. Nebivolol is a beta-1 adrenergic receptor antagonist that works via beta-1 receptor blockade; hence, it classifies as a cardioselective beta-blocker.
- Coronary heart disease (CHD) prevention of angina attacks.
- Chronic heart failure (as part of combination therapy).
GUARANTEE & EXPIRY DAY
100% original from the Russian OZON. Expiry date up to 11.2025. Product photo may vary.
Nebivolol is an FDA-approved medication used to treat hypertension. Beta-blockers are a class of agents used to treat multiple conditions such as hypertension, angina, arrhythmias, anxiety, hyperthyroidism, migraine prevention, and prevent essential tremors. Notably, the American College of Cardiology (ACC) /American Heart Association (AHA) guidelines does not recommend beta-blockers as initial antihypertensive therapy in most circumstances. Nebivolol reaches a peak plasma concentration after 1.5 to 4 hours. Food does not modify the pharmacokinetics of nebivolol. Therefore, Nebivolol tablets may be administered without regard to meals.
PACKAGE & DOSAGE
The medicine comes in the form of tablets.
Active ingredient: Nebivolol 5 mg.
In a patient with hypertension, the dose of nebivolol should be recommended based on the patient's individual needs. The recommended starting dose for most patients is 5 mg once daily, and patients can take it without respect to food. If further reduction in blood pressure is necessary, the dose can be titrated up at 2 to 4-week intervals based on the clinical response. The maximum dose is 40 mg once daily. Nebivolol is a CYP2D6 substrate, and drug-drug interaction should be considered before prescribing nebivolol. A recent review suggests that nebivolol is also effective in African-American patients with hypertension, who have been identified as a population who respond less to beta-blockers than people of other ethnicities.
Nebivolol should never be stopped abruptly, and taper-off medicine is recommended if the patient needs to stop using nebivolol. Rebound hypertension, tachycardia, exacerbation of cardiac arrhythmia, and hospitalization are reported when beta-blockers are stopped abruptly.
The medicine must be stored at temperatures 2-30°C. Keep away from children and pet animals.
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