FENBENDAZOLE a broad-spectrum benzimidazole anthelmintic primarily used in veterinary medicine to treat parasitic infections like roundworms, hookworms and whipworms.
USES
- Treat parasitic infections
GUARANTEE & EXPIRY DATE
100% original from various Indian pharmaceutical manufacturers. Product photo may vary. All packs are air tight sealed and expire up to 02.2029.
DESCRIPTION
Fenbendazole, originally designed to cure parasites, selectively blocks the synthesis of microtubules by binding to β-tubulin. This action stops the polymerization of tubulin dimers in parasite cells, leading to their death. Surprisingly, fenbendazole, along with other benzimidazoles, exhibits similar effects against tumor cells.
Fenbendazole’s anti-tumor effect is thought to occur through its interaction with β-tubulin, leading to cell cycle arrest and cytotoxicity. The inhibition of tubulin polymerization into microtubules by benzimidazole carbamates in both helminths and human tumor cells.
Malignant cells are known for their high glucose uptake, consuming glucose 200 times faster than ordinary cells due to aerobic glycolysis (Warburg effect). Fenbendazole limits cancer cell fueling by:
- Reducing glucose uptake.
- Decreasing the number of GLUT transporters (channels that transport glucose into cancer cells from the blood).
- Inhibiting the enzyme hexokinase 2, crucial for cancer cell survival. This enzyme helps tumors thrive by generating more sugar and accelerating lactic acidosis in the extracellular matrix.
Fenbendazole is not a target for p-glycoproteins, so it cannot be excreted out of cancer cells once it gets inside. Therefore, the tumors don’t develop resistance against fenbendazole. It will still remain effective and kill cancer cells, which does not seem to be the case with a lot of other chemotherapy.
PACKAGING & DOSAGE
One pack contains 50 tablets.
Active ingredient: Fenbendazole.
Excipients: Lactose, starch, povidone, microcrystalline cellulose
Fenbendazole not approved by the FDA for human use, and its safety, toxicity, and efficacy in humans are unknown.
SIDE EFFECTS AND PRECAUTIONS
- Usually well-tolerated in animals.
- Possible mild gastrointestinal issues (vomiting, diarrhea).
- Rare allergic reactions or hypersensitivity.
- Fenbendazole is not approved by the FDA for human use, and its safety, toxicity, and efficacy in humans are unknown.
STORAGE
Store in dry place at room temperature. Do not exceed storage temperature higher than 25 degrees Celcius. Keep away from direct sunlight. Keep locked and away from children.
QUESTIONS?
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