UNITHIOL (DMPS, Dimercaprol) - has been used in the management of acute and chronic poisoning with a number of different metals and metalloids, and is particularly useful for arsenic, bismuth and mercury. Unithiol can be given parenterally or orally depending on the clinical situation and severity of poisoning. It is well tolerated and adverse effects are relatively  rare. Most  common adverse effects are skin reactions such as rashes, pruritis and blistering which are allergic in origin. Most resolve within a few days and generally no treatment is required.

USES

• Has a detoxicating effect.
• Antidote in case of intoxications by arsenic and heavy metals salts.
• Peripheral nervous system state improvement.
• Capillaries permeability normalization.

GUARANTEE & EXPIRY DATE
Original from the Russian Ferrein Pharmaceutical Company. All packs are air tight sealed and expire up to 10.2029.

DESCRIPTION
Due to the presence of sulfhydryl groups, dimercaprol forms water-soluble non-toxic complexes with blockers of thiol groups of enzymes (thiol poisons in blood and tissues, decay products of ethanol), accelerating their elimination from the body. Strong binding to the blockers of sulfhydryl groups and the rapid elimination of the resulting complexes prevents the binding of the thiol groups of enzymes, helps to restore their activity and leads to a reduction and complete elimination of the symptoms of poisoning. Increases the elimination of certain cations (especially copper and zinc) from metal-containing cell enzymes. In patients with diabetic polyneuropathy, it helps to reduce pain, improve the function of the peripheral nervous system, and normalize capillary permeability.

PACKAGING
Unithiol comes in the form of ampuls for injection, 10 ampuls per pack.
Active ingredient: Unithiol 50mg/ml, 5ml/ampul.
Excipients: Water for injection.

DOSAGE
Intramuscularly, subcutaneously.
In case of arsenic intoxication: 250-500 mg (5-10 ml of the drug), at the rate of 50 mg per 10 kg of body weight, 3-4 times on the first day, 2-3 times on the second day, 1-2 times on the subsequent days.
In case of poisoning with mercury compounds: according to the same scheme for 6-7 days. Treatment is carried out until the signs of intoxication disappear.
With digitalis intoxication: in the first two days, 250-500 mg (5-10 ml of the drug) are administered 3-4 times a day, then 1-2 times a day until the cardiotoxic effect stops.
With hepatocerebral dystrophy: intramuscularly 250-500 mg (5-10 ml of the drug) daily or every other day; course of treatment 25–30 injections; if necessary, repeat after 3-4 months.

SIDE EFFECTS AND PRECAUTIONS
Possible: nausea, dizziness, tachycardia, pallor of the skin (with prolonged use in high doses).

STORAGE
Store in dry place at room temperature. Do not exceed storage temperature higher than 25 degrees Celcius. Keep away from direct sunlight. Keep locked and away from children.

QUESTIONS?
Ask us any questions about Unithiol.