TRANEXAMIC ACID (Cyklokapron) treats or prevents bleeding from major trauma, surgery, heavy menstrual periods, childbirth, nosebleeds, and hereditary angioedema. It is commonly used in both emergency and scheduled procedures to manage hemorrhage.

USES

• Heavy menstrual bleeding.
• Epistaxis, hematuria, hereditary angioedema.
• Major trauma, surgery.

GUARANTEE & EXPIRY DATE
100% original from various Russian pharmaceutical manufacturers. Product photo may vary. All packs are air tight sealed and expire up to 04.2029.

DESCRIPTION
Tranexamic acid (Cyklokapron) works by inhibiting fibrinolysis, the process that breaks down blood clots. It is a synthetic derivative of lysine that competitively and reversibly binds to lysine receptor sites on plasminogen, preventing plasminogen from being converted to plasmin, an enzyme that degrades fibrin clots.

By blocking the binding of plasminogen to fibrin, tranexamic acid stabilizes the fibrin matrix and preserves blood clots, thus preventing or reducing excessive bleeding. It also weakly inhibits plasmin activity and can block urokinase plasminogen activator, further contributing to its antifibrinolytic effect.

Tranexamic acid was first synthesized in 1962 and is now listed as an essential medicine by the World Health Organization due to its critical role in management of acute and chronic bleeding disorders.

Benefits:

• Reduces deaths from trauma-induced bleeding when administered within 3 hours.
• Decreases need for transfusions and additional treatments for hemorrhage.
• Treats heavy periods, and used after childbirth to control postpartum bleeding.
• Improves quality of life for patients with chronic bleeding issues.

Further read: https://en.wikipedia.org/wiki/Tranexamic_acid

PACKAGING & DOSAGE
One pack contains 50 tabs of 250 mg or 500 mg.
Active ingredient: Tranexamic acid 250 mg or 500 mg.
Excipients: Microcrystalline cellulose, povidone, croscarmellose sodium, colloidal anhydrous sílica, magnesium stearate, purified talc, eudragit E 100, titanium dioxide, macrogol 8000, vanillin.

Common Dosage Regimens:

• General use (500 mg tablets):
  1,000–1,500 mg (2–3 tablets) two or three times daily.
• Heavy menstrual bleeding (menorrhagia):
  1,000 mg (2 tablets) three times daily for up to 4 days (maximum 4,000 mg/day).
• Epistaxis, hematuria, surgery, hereditary angioedema:
  Doses generally range from 1,000–1,500 mg two to three times daily, adjusted to body weight (15–25 mg/kg/dose).

Caution is advised with concurrent use of medications increasing clot risk, such as estrogens. Contraindicated in patients with active thromboembolism, history of seizures, severe renal impairment, or inherited color vision defects.

• Gastrointestinal: nausea, vomiting, diarrhea.
• Dizziness, headache, vision changes.
• Allergic: rash, swelling, trouble breathing (rare).

STORAGE
Store in dry place at room temperature. Do not exceed storage temperature higher than 25 degrees Celcius. Keep away from direct sunlight. Keep locked and away from children.

QUESTIONS?
Ask us any questions about Tranexamic acid.