SANDIMMUN NEORAL® (Cyclosporine) is a strong immunosuppressant that calms down your immune system to stop it from attacking your own body or a new organ. It's like a shield for transplants or severe skin/joint problems when other treatments don’t work.
USES
- Prevents your body from rejecting a transplanted kidney, liver, or heart.
- Treats bad cases of psoriasis (scaly skin), rheumatoid arthritis (painful swollen joints), or eczema when nothing else helps.
GUARANTEE & EXPIRY DATE
100% original from various Indian pharmaceutical manufacturers. Product photo may vary. All packs are air tight sealed and expire up to 02.2029.
DESCRIPTION
Sandimmun Neoral® (cyclosporine) is an immunosuppressant that calms overactive immune responses to prevent organ rejection after transplants or to treat severe autoimmune conditions where the body mistakenly attacks its own tissues.
Cyclosporine revolutionized transplant by allowing patients' bodies to accept donated kidneys, livers, hearts, or bone marrow without immediate rejection. Unlike older steroids, it specifically targets T-cells—key immune soldiers—by blocking an enzyme called calcineurin, which stops these cells from multiplying and releasing inflammation-causing chemicals like interleukin-2. This selective action reduces immune overreactions without completely shutting down the body's defenses against infections, though it still lowers overall immunity.
Benefits:
- Keeps transplants working longer.
- Clears up severe skin rashes or eases joint pain fast.
- Lets some people cut back on stronger steroid pills.
Read further: https://en.wikipedia.org/wiki/Ciclosporin
PACKAGING & DOSAGE
One package contains 50 caps. Available in the strength of 25, 50 or 100 mg.
Active ingredient: Cyclosporine 25, 50 or 100 mg.
Excipients: Ethanol propylene glycol, macrogolglycerol hydroxystearate, corn oil-mono-di-triglycerides, DL-alpha-tocopherol (vitamin E), gelatin (capsule shell), glycerol, iron oxide.
Transplant Dosing (kidney, liver, heart):
Pre-transplant (4-12 hours before): 14-18 mg/kg oral once, or 5-6 mg/kg IV over 2-6 hours. First 1-2 weeks post-op: 5-15 mg/kg/day oral, split twice daily. Maintenance (after tapering 5% weekly): 5-10 mg/kg/day oral, split twice daily—lower over time (e.g., 3-5 mg/kg/day long-term).
Non-Transplant (e.g., rheumatoid arthritis, psoriasis):
Start: 1.25-2.5 mg/kg/day oral, split twice daily. Adjust: Increase by 0.5-0.75 mg/kg/day every 8-12 weeks if needed, max 4 mg/kg/day. Psoriasis: Up to 4-5 mg/kg/day short-term (under 1 year).
VIDEO
SIDE EFFECTS AND PRECAUTIONS
- High blood pressure, kidney strain (needs regular pee/blood checks), extra hair growth, swollen gums, shaky hands, headaches, more infections (like colds or flu).
- Don't use if you have weak kidneys, infections, or cancer history.
- Avoid grapefruit, St. John's wort, they mess with how it works.
STORAGE
Store in dry place at room temperature. Do not exceed storage temperature higher than 25 degrees Celcius. Keep away from direct sunlight. Keep locked and away from children.
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