Metadoxil is the pharmaceutical version of Metadoxine with guaranteed quality by Italian Laboratori Baldacci SpA.
This medication works by accelerating the clearance of alcohol from the blood. It is also being used nowadays for the treatment of ADHD (attention deficit hyperactivity syndrome) and Fragile X syndrome.
How does Metadoxine work?
Metadoxine is composed of pyroglutamic acid and vitamin B6. This medication acts as an antagonist of the 5-HT2B receptor. Scientific evidence shows that it decreases that activity of GABA transaminase enzyme. In vitro experiment shows that this drug succeeded in reducing alcohol dehydrogenase activity.
Treat acute alcohol intoxication
In clinical studies, metadoxine has been reported to reduce half-life of ethanol in healthy volunteers and in acutely intoxicated patients; to accelerate the metabolism of alcohol and acetaldehyde into less toxic higher ketones and to improve their urinary clearance; to restore laboratory variables such as alcohol, ammonia, γ-GT, and alanine aminotransferase; and to improve clinical symptoms of alcohol intoxication, including psychomotor agitation, depression, aggressiveness, and equilibrium disorders. There is also evidence that metadoxine has an effect on reducing craving for alcohol. Data from clinical studies also support an effect of metadoxine on reducing indices of liver cell necrosis and fat accumulation in alcoholic fatty liver.
Metadoxine is predominantly used as immediate release formulation in developing nations for acute alcohol intoxication and chronic alcoholic liver disease. Alternate names include:
Abrixone (Eurodrug, Mexico)
Alcotel (Il Yang, South Korea)
Ganxin (Qidu Pharmaceutical, China)
Metadoxil (Baldacci, Georgia; Baldacci, Italy; Baldacci, Lithuania; CSC, Russian Federation; Eurodrug, Colombia; Eurodrug, Hungary; Eurodrug, Thailand)
NEXT LABS (India)
Alkodez ІС (Ukraine)
Viboliv (Dr. Reddy's, India)
EXTOL (Next Labs, India)
Xin Li De (Zhenyuan Pharm, China)
Research and clinical trials