METADOXIL (Metadoxine) 500 mg/tab, 30 tab/pack

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METADOXINE - is able to accelerate the elimination of alcohol from the blood and tissues, to help restore the functional structure of the liver and to relieve neuro-psychological disorders associated with alcohol intoxication. Metadoxine also seems to be safe; in more than 15 years of post-marketing surveillance only minor aspecific and reversible events were monitored in patients exposed to the treatment. In this review the preclinical and clinical results obtained using metadoxine in acute and chronic alcohol intoxication are reported.


  • Alcohol Intoxication.
  • Chronic Alcoholism.
  • Alcohol Withdrawal Syndrome.
  • Complex Therapy of Liver Diseases, Especially Alcohol Etiology.

100% original from Italian Laboratori Baldacci SpA. All packs are air tight sealed and expire up to 05.2026.

Metadoxine is an active drug for treatment of acute and chronic alcohol intoxication, affecting both liver and brain function. The authors reviewed the international pharmacological and clinical literature on the drug which shows the potential usefulness of metadoxine in the treatment of alcohol-induced diseases. The case report concerns the results in 20 chronic alcoholics, admitted to the hospital for acute alcohol intake treated with metadoxine (one 500 mg tablet twice daily). Biohumoral hepatopathy parameters and clinical parameters of neuropsychic behaviour were examined simultaneously. Compared with a control group of patients undergoing traditional therapy (sedative and multi-vitamin drugs), metadoxine showed a significant improvement of the values of gamma-GT, GPT, blood ammonia, blood alcohol and of neuropsychic and behavioural parameters such as agitation, tremor, asterixis, sopor and depression. No side-effects or unfavourable reactions occurred during metadoxine treatment, which confirms the safety of this molecule.

Metadoxil comes in the form of tablets: 500 mg per tablet, 30 tablets per pack.

Active ingredient:
Pyridoxine L-2 pyrrolidone 5-carboxylate (methadoxine) - 500 mg

Microcrystalline cellulose, magnesium stearate.

Combined therapy for chronic alcoholism: 1 tablet 2 times a day (1000 mg) 15-30 minutes before meals, the dose can be increased to 3 tablets (1500 mg) per day. The course of therapy should be at least 90 days.


  • With caution Metadoxine should be prescribed for Parkinson's disease if levodopa is used at the same time, because metadoxine reduces the effectiveness of the latter.

Allergic reactions.
In patients with bronchial asthma, bronchospasm may develop with the use of an injection.

Store in dry place at room temperature. Do not exceed storage temperature higher than 25 degrees Celcius. Keep away from direct sunlight. Keep locked and away from children.

Ask us any questions about Metadoxil.


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