VORTIXET (Vortioxetine) is a multimodal antidepressant used primarily for the treatment of major depressive disorder (MDD). It functions as a serotonin modulator and stimulator with a unique mechanism combining serotonin reuptake inhibition and direct modulation of multiple serotonin receptors to improve mood, cognition, and anxiety symptoms.
USES
Major Depressive Disorder (MDD) treatment to improve depressive symptoms and cognitive function.
Sometimes used off-label for generalized anxiety disorder and other mood disorders.
GUARANTEE & EXPIRY DATE 100% original from various Indian pharmaceutical manufacturers. Product photo may vary. All packs are air tight sealed and expire up to 06.2028.
DESCRIPTION
Vortixet (Vortioxetine) works by inhibiting the serotonin transporter (SERT), increasing serotonin levels in the brain's synaptic clefts. Uniquely, it also directly modulates several serotonin receptor subtypes: acting as a 5-HT1A receptor agonist, a partial agonist at 5-HT1B receptors, and an antagonist at 5-HT3, 5-HT1D, and 5-HT7 receptors. These combined actions enhance neurotransmitter balance beyond serotonin, influencing dopamine, norepinephrine, acetylcholine, histamine, GABA, and glutamate neurotransmission, which may underlie its antidepressant and pro-cognitive benefits.
Benefits:
Reduces depressive symptoms with improved cognitive function compared to traditional SSRIs.
May cause fewer sexual side effects due to partial serotonin transporter inhibition.
Benefits on anxiety symptoms often accompanying depression.
Potential improvement in sleep architecture due to antagonist action at 5-HT3 receptors.
Initial dose typically 10 mg once daily, adjustable up to 20 mg daily depending on response and tolerability.
SIDE EFFECTS AND PRECAUTIONS
Nausea, headache, dizziness, diarrhea.
Possible sexual dysfunction, although lower compared to other SSRIs.
Avoid combining with other serotonergic drugs or MAO inhibitors to minimize serotonin syndrome risk.
Avoid abrupt discontinuation to prevent withdrawal symptoms.
STORAGE Store in dry place at room temperature. Do not exceed storage temperature higher than 25 degrees Celcius. Keep away from direct sunlight. Keep locked and away from children.
Vortioxetine is an antidepressant. It is used to treat major depressive disorder (MDD). It is known for its multimodal mechanism of action, affecting various neurotransmitters in the brain to improve...
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