TOFACITINIB is an orally administered JAK inhibitor with a specific chemical structure that enables targeted immunomodulation in autoimmune conditions, balancing efficacy with safety considerations.
USES
Rheumatoid arthritis (moderate to severe).
Psoriatic arthritis.
Ankylosing spondylitis.
Ulcerative colitis (maintenance therapy after induction).
GUARANTEE & EXPIRY DATE 100% original from various Indian pharmaceutical manufacturers. Product photo may vary. All packs are air tight sealed and expire up to 02.2028.
DESCRIPTION
Tofacitinib modulates the immune system by inhibiting JAK enzymes involved in inflammatory pathways, thus reducing joint inflammation, pain, and immune activity. Tofacitinib is a potent Janus kinase (JAK) inhibitor used primarily in the treatment of autoimmune diseases such as rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis.
A Janus kinase (JAK) inhibitor is a type of treatment that blocks the activity of one or more enzymes in the Janus kinase family (JAK1, JAK2, JAK3, TYK2), which are critical for signaling in the immune system. These enzymes transmit signals from cytokines—proteins that regulate immune responses—by activating the JAK-STAT (Signal Transducer and Activator of Transcription) pathway inside cells.
Benefits:
Reduces inflammation, joint pain, and swelling.
Improves physical function and quality of life.
Oral administration offers convenience over injectable biologics.
Recommended dose: 5 mg orally twice daily, with or without food.
For ulcerative colitis: induction dose is 10 mg twice daily for 8–16 weeks, then maintenance at 5 mg twice daily.
SIDE EFFECTS AND PRECAUTIONS Upper respiratory infections, headache, diarrhea, nasopharyngitis. Avoid in active infections or history of recurrent infections. Caution with cardiovascular risks, malignancies, and immunosuppression
STORAGE Store in dry place at room temperature. Do not exceed storage temperature higher than 25 degrees Celcius. Keep away from direct sunlight. Keep locked and away from children.
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