SELEGILINE is used for Parkinson's disease and, in some formulations, for major depressive disorder. It increases dopamine levels in the brain, improving movement control and providing symptomatic relief in Parkinson’s patients.

USES

• Parkinson’s disease.
• Major depressive disorder.

GUARANTEE & EXPIRY DATE
100% original from various Russian pharmaceutical manufacturers. Product photo may vary. All packs are air tight sealed and expire up to 11.2027.

DESCRIPTION
Selegiline is a selective, irreversible inhibitor of monoamine oxidase B (MAO-B), used chiefly for Parkinson’s disease and, at higher doses, for major depressive disorder. It works by enhancing levels of dopamine and, at increased doses, serotonin and norepinephrine in the central nervous system.

Selegiline binds to and inactivates the MAO-B enzyme, which is present in high concentrations in regions of the brain associated with movement and mood. By inhibiting MAO-B, it blocks the breakdown (oxidative deamination) of dopamine, allowing higher levels of dopamine at synaptic sites in the basal ganglia and other brain regions. When given at higher doses, selegiline can also inhibit MAO-A, raising levels of serotonin and norepinephrine.

Selegiline improves movement and mood by increasing dopamine availability in Parkinson’s and, at higher doses, broadens monoaminergic neurotransmission to include serotonin and norepinephrine for depression therapy.

Benefits

• Improves movement and muscle control in Parkinson’s disease.
• May delay disease progression and extend levodopa efficacy.
• Provides modest antidepressant effects, comparable to other antidepressants.

Further read: https://en.wikipedia.org/wiki/Selegiline

PACKAGING & DOSAGE
One pack contains 50 tablets of 5 mg.
Active ingredient: Selegiline hydrochloride 5 mg.
Excipients: Microcrystalline cellulose, magnesium stearate, anhydrous lactose, citric acid, mannitol.

Parkinson’s disease: Typically 5–10 mg/day orally.
Depression (transdermal): Initial 6 mg/day; can increase up to 12 mg/day if needed.
Dosage adjustments may be necessary for age, renal, hepatic function, concomitant medications, or response.

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SIDE EFFECTS AND PRECAUTIONS

• Dry mouth.
• Nausea.
• Difficulty sleeping/insomnia.
• Abdominal pain.
• Constipation.

Do not use with other MAOIs or certain antidepressants to avoid serotonin syndrome. Avoid foods rich in tyramine (aged cheese, cured meats) to prevent hypertensive crisis, especially at high doses. Discontinue gradually to avoid withdrawal symptoms.

STORAGE
Store in dry place at room temperature. Do not exceed storage temperature higher than 25 degrees Celcius. Keep away from direct sunlight. Keep locked and away from children.

QUESTIONS?
Ask us any questions about Selegiline.