LETROZOLE (Femara) is a selective, nonsteroidal aromatase inhibitor used to treat hormone receptor-positive breast cancer in postmenopausal women by reducing estrogen production in the body.
USES
Breast cancer (for post-menopausal women).
GUARANTEE & EXPIRY DATE 100% original from various Russian pharmaceutical manufacturers. Product photo may vary. All packs are air tight sealed and expire up to 02.2029.
DESCRIPTION
Letrozole (Femara) was patented in 1986, approved for medical use in 1996, and is marketed under the brand name "Femara." It works by selectively blocking the aromatase enzyme, which converts androgens to estrogens in peripheral tissues. This effect sharply reduces circulating estrogen, inhibiting the growth of estrogen-dependent cancer cells in postmenopausal women. It is not effective in premenopausal women for breast cancer because their primary source of estrogen is ovarian, not peripheral, and is recommended as a first-line medication for ovulation induction in women with PCOS.
Letrozole (Femara) binds reversibly to the heme group of the aromatase enzyme cytochrome P450 unit, potently and specifically inhibiting peripheral estrogen synthesis. In postmenopausal women, it reduces estradiol, estrone, and estrone sulfate concentrations by up to 95%, without impairing adrenal steroidogenesis. Letrozole is considered more potent than other aromatase inhibitors like anastrozole and exemestane for this inhibition.
Benefits:
Reduces risk of breast cancer recurrence and improves disease-free survival rates in postmenopausal women with hormone-sensitive cancers
Provides alternative ovulation induction in women with PCOS, with higher live birth rates compared to clomiphene
Well-established and included in major international cancer protocols.
Excipients: Lactose monohydrate, microcrystalline cellulose, colloidal anhydrous silica, magnesium stearate, maize starch, sodium starch glycolate, and a film-coating composed of substances like lactose, macrogol, and pigment.
Standard recommended dose: 2.5 mg taken orally once daily, with or without food. Duration depends on the indication; typically up to 5 years as adjuvant therapy or as directed for ovulation induction.
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SIDE EFFECTS AND PRECAUTIONS
Hot flashes, sweating, and flushing.
Fatigue and lack of energy.
Arthralgia (joint/muscle pain), bone pain, headache.
Can cause dizziness and fatigue, so caution is advised when driving or operating machinery.
STORAGE Store in dry place at room temperature. Do not exceed storage temperature higher than 25 degrees Celcius. Keep away from direct sunlight. Keep locked and away from children.
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