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PROPOFOL (aka Diprivan) - is a hypnotic/amnestic agent used for induction and maintenance of general anesthesia for surgery or other medical procedures, as well as for sedation of mechanically ventilated adults. Sedative/anesthetic effects of Propofol are produced by the positive modulation of the inhibitory function of the neurotransmitter GABA through the ligand-gated GABAa-receptors. GABA (gamma-Aminobutyric acid) is an inhibitory neurotransmitter in the central nervous system. Activation of GABAA receptors increases transmembrane chloride conductance, which results in hyperpolarization of the postsynaptic cell membrane and functional inhibition of the postsynaptic neuron.
GUARANTEE & EXPIRY DATE
100% Original pharmacy product from German Fresenius Kabi AG https://www.fresenius-kabi.com/sites/global/Pages/Company.aspx. This is not a cheap chinese generic replica in a plastic bag or foil pouch with unknown ingredients.
All packs are air tight sealed and expire up to 09.2021.
Propofol is a short-acting intravenous hypnotic/amnestic medicine. Its is administered for the induction and maintenance of general anesthesia, sedation for mechanically ventilated adults, and procedural sedation. Propofol potentiates GABAA-receptor activity, thereby slowing the channel-closing time, and also acting as a sodium channel blocker. When the GABA-receptor is activated, transmembrane chloride conduction is potentiated, resulting in hyperpolarization of the postsynaptic cell membrane and functional inhibition of the neuron. Further read: https://en.wikipedia.org/wiki/Propofol.
INSTRUCTIONS & DOSAGE
Active substance: propofol 10mg
Excipients: soybean oil, egg lecithin, glycerol, oleic acid, sodium hydroxide, water for injections
Propofol is individually administrated as an intravenous injection.
Induction Of General Anesthesia:
Adults: 20-40mg every 10 seconds until the clinical signs show the onset of anesthesia.
Patients over 55yo and classified as ASA-PS I or II require 1,5-2,5mg/kg.
Children over 3yo: slow injection until the clinical signs show the onset of anesthesia.
Children over 8yo - 2,5mg/kg.
Maintenance Of General Anesthesia:
Adults: as a long-term infusion (usual dose is 6-12mg/kg) or intermittent IV bolus injection.
Patients over 55yo and classified as ASA-PS III or IV: the dose is reduced to minimal 4mg/kg/hour; the dose of bolus injection is 25-50mg.
Children over 3yo: as a long-term infusion or intermittent IV bolus injection, usual dose is 9-15mg/kg/hour.
Intensive Care Unit sedation:
For intubated, mechanically ventilated adult patients: Propofol should be initiated slowly with a continuous infusion - 0,3-0,4mg/kg/hour.
Surgeries and diagnostic procedures: usual induction dose is 0,5-1mg for 1-5min, maintenance dose is 1,5-4,5mg/kg/hour.
Store in dry place at room temperature. Do not exceed storage temperature higher than 25 degrees Celcius. Keep away from direct sunlight. Keep locked and away from children.
Please note that you are responsible for your country's customs clearance, taxes and duties in your country. Any packages returned back to us by the customs will be eligeble for a refund minus the P&P costs. Due to the nature of the product we cannot accept returns. Your statutory rights are not affected.
Ask us any questions about Propofol. We speak English and Russian.